How to: A guide to microdosing

What is microdosing?

Microdosing is a way of consuming psychedelics with a specific intention in mind. The keyword here is “intention” as it can make a world of difference to the action that is being done. An intention is a conscious aim tied to an embodied action in the future.

The amount in a microdose is “subperceptual” meaning that it does not make someone trip, but the effects are cumulative or add up in the following weeks and months resulting in enhanced mood regulation, better eating and sleeping habits, and less of a need for caffeine.

Anecdotal accounts already suggest that microdosing is not for everyone. For those who have any sort of bipolar or psychosis history, there is the possibility of overstimulation.

How microdosing magic mushroom feels


About an hour or two after ingesting the microdose, people notice an increase in focus and energy. Many users find that it helps with weaning off — and staying off — anti-depressants. It can help lessen the side effects of withdrawal and even mitigate depression.

Many speak to the drug’s ability to increase empathy, too. Some reports include increased clarity of thoughts and reduced mental fog. Mounting evidence now points to the effects mentioned.

How to microdose

Microdosing involves taking 1/10th of a macrodose periodically. A regular macrodose usually falls in the range of 2 to 3 grams of dried mushrooms. For most people, morning is the best time because the beneficial effects will last throughout the day without interfering with sleep. Psilocybin is an acid, so it is therefore best to take a microdose with breakfast, so that it doesn’t increase stomach acidity and cause discomfort. In terms of periodicity, the following regimens can be chosen.

Method 1: Dr. Fadiman’s Approach (1 microdose every 3 days)

Dr. Fadiman recommends taking one microdose every 3 days so as to prevent changes in tolerance over time. He says,“the first day you feel great. The second day you would feel half of that. And the third day you won’t feel anything.” This regimen is a classic.

Week 1: Sat/Tue/Fri
Week 2: Sun/Wed/Sat

Dosage: It’s best if you start microdosing on a weekend as this will give you a chance to notice any unusual effects before microdosing in a more public situation. Dosage varies from 0.2 to 0.3g of microdose, the latter being the choice for creativity enhancement but not recommended for anxiety management as it is a bit on the high side.

Note: Some reports suggest that in one-year experiments tolerance build-up was not the case when microdosing almost every day (3–6 times per week). In fact, some noticed the opposite effect — a buildup of effects if one took too many doses in a row, such that the third day in a row of taking 0.2g felt like one was taking 0.4g. However, your mileage may vary, and there’s no doubt that there are other reasons Dr. Fadiman recommends this protocol.


Method 2: Paul Stamets’ protocol (weekdays on, weekends off):

This plan is geared towards individuals looking to test microdosing for potential improvements at work. It can also be good for students who want an alternative to caffeine driven study hours.

The weekends are left open for recovery to baseline, in case of changes in effect over time.

Week 1: Mon/Tue/Wed/Thu/Fri
Week 2: Mon/Tue/Wed/Thu/Fri

Dosage: A good dosage for this would be 0.2g.

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